The disliked painting by Rosso Fiorentino

Video in Italian | The patron who commissioned the work felt as if the painter had been willing to laugh at him

Commissioned from Rosso Fiorentino and executed in 1518, this altarpiece known as Pala dello Spedalingo was originally scorned by its patron because in the strange, bizarre and frowning figures of the composition, he saw a painter's attempt to laught at him. So, he refused to pay the artist. Today, it is proudly displayed at the Uffizi instead.

So what's wrong with this work?